Proteoglycans or mucoproteins are formed through connecting proteins and polysaccharide in the way of covalence and non covalent bond in connective tissue. Their molecular organization is mainly polysaccharide chains, and the proportion of protein is small. There are several polypeptide chains in a polysaccharide, with above one million molecular weights.

Oversulfated chondroitin sulfate: Chs is treated with the use of chemical method to prepare ChPs; with control conditions, it can possess proper molecular weight, sulfur content, and several biological activities.